Comparing nebulised lignocaine and intravenous dexmedetomidine in response of airway instrumentation.

Comparison of attenuation of hemodynamic pressor response to laryngoscopy and endotracheal intubation with intravenous Dexmedetomidine versus nebulized 4% solution of lignocaine versus combination of Both in patients undergoing laparoscopic cholecystectomy surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/07/026918

Enrollment

Registered

2020-07-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K804- Calculus of bile duct with cholecystitis

Interventions

Intervention1: 4 % lignocaine: Dose - 3mg/kg Route - via a face mask and cirrus nebulizer with Oxygen Duration - 10 minutes or till the whole drug is used

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to ASA Grade I - II status posted for laparoscopic Cholecystectomy Surgery,Securing airway within 30 seconds,Airway examination: Mallampatti Grade- 1,2; Neck Extension > 6.5cm, Mouth Opening > 3 fingers, Age group: 18 to 50 years

Exclusion criteria

Exclusion criteria: 1. The patients who did not give consent 2. The American society of anesthesiology (ASA) physical status > II 3. Weight: 70kg 4. Anticipated difficult airway (Mallampati Grade-3,4; Cormack-Lehane Grade-3,4), short neck 5. Patients with history of any medication or substance abuse 6. Age: 50 years 7. BMI more than 30 8. Height: 180cm 9. Base line Heart rate: =90bpm. 10. Baseline Blood pressure: =140/85(105) mmhg. 11. Smokers, history of any respiratory disease, gastro esophageal reflux disease. 12. Patients taking antihypertensive or any alpha-2 agonist 13. No postural hypotension

Design outcomes

Primary

Measure	Time frame
To find out the change in heart rate and mean blood pressure( in terms of 20% rise from baseline values) in three groups of patients undergoing laparoscopic Cholecystectomy, namely : 1. Group â??Dâ?? (intravenous Dexmedetomidine group), 2. Group â??Lâ?? (nebulized 4% Lignocaine) and 3. Group â??DLâ?? (combination of Both) Timepoint: Heart rate, Systolic Blood Pressure, Diastolic Blood Pressure and Mean Arterial Pressure measured at Baseline, Before Nebulization ,After Nebulizaton, Before Infusion, Before Laryngoscopy and After Intubation at 1, 3, 5, 7, 10 minutes.	—

Measure

Time frame

To find out the change in heart rate and mean blood pressure( in terms of 20% rise from baseline values) in three groups of patients undergoing laparoscopic Cholecystectomy, namely : 1. Group â??Dâ?? (intravenous Dexmedetomidine group), 2. Group â??Lâ?? (nebulized 4% Lignocaine) and 3. Group â??DLâ?? (combination of Both) Timepoint: Heart rate, Systolic Blood Pressure, Diastolic Blood Pressure and Mean Arterial Pressure measured at Baseline, Before Nebulization ,After Nebulizaton, Before Infusion, Before Laryngoscopy and After Intubation at 1, 3, 5, 7, 10 minutes.

—

Secondary

Measure	Time frame
not applicableTimepoint: 0	—

Countries

India

Contacts

Public ContactZeeshan Haider warsi

IMS AND SUM HOSPITAL

bhavna.sriramka@gmail.com7751007807

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026