Health Condition 1: E240- Pituitary-dependent Cushings disease
Conditions
Interventions
Control Intervention1: No intervention planned: Compare the mutation status and protein expression level differences in pituitary adenomas removed from patients with and without Cushings syndrome
Cont
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. All consecutive cases of corticotroph adenomas diagnosed on resection specimens from 2002-2022 2. Clinical functional status known 3. Clinically functioning (i.e. Cushing disease) adenomas with T-pit + ACTH expression or clinically nonfunctioning adenomas with T-pit ± ACTH expression. 4. Adequate tumor tissue in the formalin fixed paraffin embedded blocks
Exclusion criteria
Exclusion criteria: 1. Corticotroph pituitary hyperplasia 2. Adenoma with apoplexy 3. Inadequate data on clinical functional status 4. Double adenomas/pluri-hormonal adenomas expressing ACTH
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in the protein expression levels of activation markers of EGFR-MAPK, NFKB, and SHH signaling pathways and mutation status of USP8, USP48, and BRAFV600E genes between functional and silent corticotroph adenomasTimepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Classification of corticotroph adenomas into different morpho-functional types as per WHO 2017 classification based on clinical functional status, ACTH granulation and TPIT expressionTimepoint: 3 years;Prevalence and clinico-radiologic-pathological features (including proliferative index) of the different morpho-functional subtypes, and their correlation with clinical outcomeTimepoint: 3 years | — |
Countries
India
Contacts
Public ContactAruna Nambirajan
All India Insitiute of Medical Sciences, New Delhi, India
Outcome results
None listed