Health Condition 1: H178- Other corneal scars and opacities
Conditions
Interventions
Intervention1: Not Applicable: Not Applicable
Control Intervention1: Normal Saline: On procedure say patients will receive a topical collagenase treatment in the limbus region prior to the direct appl
Sponsors
The Ulverscroft Foundation
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient should be 18 years and above of age. 2. Patient should be able and prepared to complete questionnaires. 3. Patient should be diagnosed with an acute severe (grade II-IV) unilateral chemical burn. 4. Patient should not have any other ocular abnormality in the injured eye. 5. Able and willing to provide informed consent prior to any study related procedures. 6. Willingness and ability to attend for all the study visits with in required visits windows.
Exclusion criteria
Exclusion criteria: 1. The exclusion criteria include having a significant co-morbidity in which compliance with the study procedures would not be expected. 2. Unwillingness to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measures to be tested are improved visual acuity and the reduction of corneal haze and pain, determined using slit lamp biomicroscopy and clinical evaluation, respectivelyTimepoint: At each time point that is Day 1, 7, 14, 28 and months 3,6 and 12. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary qualitative outcomes on the lack of blood vessels, epithelial defect, delayed epithelial staining and opaque tissue growth on the centre of the cornea will be recorded as a diagram and photographs that will assist in confirming the condition of the cornea. Epithelial defect size will be examiner-assessed and documented digitally by anterior segment imaging at follow-up visitsTimepoint: (DPP 0), at 1, 7, 14, 28 days (epithelial closure) post-procedure (DPP) and 3, 6, and 12 months post-procedure (MPP) | — |
Countries
India
Contacts
Public ContactDr Sayan Basu
LV Prasad Eye Institute
Outcome results
None listed