Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: J128- Other viral pneumonia
Conditions
Interventions
Intervention1: High Flow Nasal Oxygen therapy: Patients allocated to HFNO arm will be applied HFNO through large-bore binasal prongs with a high flow heated humidifier device (Optiflow, Fisher and Pay
Sponsors
All India Institute of Medical Sciences New Delhi
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: One hundred adult patients (aged between 18 and 75y) with laboratory confirmed diagnosis of COVID-19 pneumonia, presenting with severe COVID-19 pneumonia, who fail oxygen therapy by facemask, will be included in this study after ethics committee approval and informed written consent from the patients or their legally acceptable representatives.
Exclusion criteria
Exclusion criteria: Following patients will be excluded i) refusal to participate, ii) hemodynamically unstable patients on high dose vasopressor therapy iii) pregnant patients iv) COPD / chronic respiratory failure v) Morbid obesity vi) Patients with urgent requirement of invasive mechanical ventilation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early intubation rate - Proportion of patients requiring invasive mechanical ventilation at 48 hours of ICU admissionTimepoint: Early intubation rate - Proportion of patients requiring invasive mechanical ventilation at 48 hours of ICU admission | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Early improvement in oxygenation â?? SpO2, RR and PaO2/FiO2 ratio in arterial blood gas at 2 hours and 24 hours 2. Late intubation rate - proportion of patients requiring invasive mechanical ventilation within day 7 of ICU admission 3. Proportion of patients requiring awake prone positioning within 48 hours 4. In-hospital mortality Timepoint: 2 hours, 24 hours, 48 hours and 7 day | — |
Countries
India
Contacts
Public ContactDalim Kumar Baidya
AIIMS New Delhi
Outcome results
None listed