Comparison of hypotensive properties of esmolol versus magnesium sulfate and their effectiveness to provide quality of surgical field during functional endoscopic sinus surgery

Comparison of hypotensive properties of esmolol versus magnesium sulfate and their effectiveness to provide quality of surgical field during functional endoscopic sinus surgery: A randomized interventional study at SMS medical college jaipur during 2019-2021

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/07/026781

Enrollment

130

Registered

2020-07-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: J329- Chronic sinusitis, unspecified

Interventions

Intervention1: Inj.esmolol: Inj.esmolol bolus 1mg/kg over 1 minute, infusion 1mg/kg/hr Control Intervention1: Inj.magnesium sulfate: Inj.magnesium sulfate LD 40mg/kg in 10ml saline over 10 minutes, in

Eligibility

Inclusion criteria

Inclusion criteria: -ASA grade 1&2 -Body weight of 45-65kg -Undergoing elective resection of nasal polyps(duration 60-70 minutes)

Exclusion criteria

Exclusion criteria: -History of allergy to these drugs -Patient with pre-existing bledding and coagulation abnormalities -History of hypertension,CAD,renal and hepatic dysfunction -Patient not willing to participate in study -Cerebral insuffciency -H/o recurrent sinus surgery -Orbital abscess -CSF leak with or without CSF Rhinorrhea

Design outcomes

Primary

Measure	Time frame
To assess and compare the hemodynamic parameters like HR, SBP, DBP, MBP from baseline at different time interval in both the groupsTimepoint: 70 minutes	—

Secondary

Measure	Time frame
to assess and compare emergence time, sedation score, VAS score in postoperative field and time to first rescue analgesia after surgeryTimepoint: 240 min;to assess and compare the quality of intraoperative surgical field in both the groupsTimepoint: Fromme and Boezaart;to find out and compare the proportion of cases with complicationsTimepoint: Bradycardia, Hypotension, tachycardia	—

Countries

India

Contacts

Public ContactDr Neelam charan

Sms medical college

Bafnausha@yahoo.com9413901579

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026