Comparison of analgesic effectiveness of Dexmedetomidine versus Clonidine as an adjuvant to bupivacaine in epidural anaesthesia in patients undergoing vaginal hysterectomy

Comparison of analgesic effectiveness of Dexmedetomidine versus Clonidine as an adjuvant to bupivacaine in epidural anaesthesia in patients undergoing vaginal hysterectomy: a randomised double blind interventional study in SMS medical college and attached group of hospitals during 2019-2021

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/07/026769

Enrollment

Registered

2020-07-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: N813- Complete uterovaginal prolapse

Interventions

Intervention1: Injection Dexmedetomidine 1 microgram/kg: injection Dexmedetomidine 1 microgm/kg with injection bupivacaine 0.5% 15ml diluted upto 20ml with normal saline epidurally Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 and 2 Patients body weight 40-70 kg Patient height >140 cm undergoing vaginal hysterectomy

Exclusion criteria

Exclusion criteria: Patient not willing to give consent Chronic history of headache backache and raised ICP. Heart block, significant bradyarrhythmias, LVF, hematological disease, deranged bleeding or coagulation profile, compromised renal, cardiac or respiratory status. H/o spinal surgery, spinal deformity or infection at local site. Diabetes, psychiatric illness, H/o drug abuse Allergic to any of concerned drugs

Design outcomes

Primary

Measure	Time frame
to evaluate difference in time duration of requirement of first rescue analgesia and total number of rescue analgesias postoperatively in both the groupsTimepoint: 240 min	—

Secondary

Measure	Time frame
to assess and compare mean duration of motor block in both groupsTimepoint: 30 min;to assess and compare mean duration of sensory block in both the groupsTimepoint: 20 min;to assess and compare number of % of cases who experience side effectsTimepoint: 2 hrs;to assess and compare the hemodynamic response intraoperativelyTimepoint: 2 hrs	—

Countries

India

Contacts

Public ContactDr C S Chatterjee

SMS Medical College

chatterjee.chandrashekhar@gmail.com9828088092

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026