Health Condition 1: K929- Disease of digestive system, unspecified
Conditions
Interventions
Intervention1: Ketamine and Dexmedetomidine: Dexmedetomidine 0.5microgram/kg +ketamine 0.25mg/kg intravenously over 10minutes
Control Intervention1: fentanyl
: Fentanyl 2microgram/kg intravenously ov
Sponsors
SVIMS
Eligibility
Inclusion criteria
Inclusion criteria: 1.All patients belonging to American Society of Anesthesiologists(ASA) physical status grade I & II. 2.Age between 18-65 years. 3.Those scheduled for elective laparotomy lasting < 4hrs duration
Exclusion criteria
Exclusion criteria: Patients who refuse to give consent to participate in the study. Patients aged 65 years. Chronic opioid users. Those with pre-existing pain syndrome. Those with severe cardiovascular (New York Heart Association class III or IV), pulmonary and renal disease. Inability to communicate and understand numerical rating scale (NRS) and QOR-40 scale. Patients with known hypersensitivity to the drugs used. Pregnant and lactating mothers. Patients with known history of psychiatric illness and chronic drug or alcohol abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the post operative recovery profile between dexmedetomidine - ketamine and fentanyl groups using QOR-40 score.Timepoint: 24 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| : To compare the duration of time to first analgesic request postoperatively,propofol sparing effect of dexmedetomidine-ketamine and fentanyl and intraoperative haemodynamic alterations. Timepoint: 1,3,5 minutes | — |
Countries
India
Contacts
Public ContactBALARAJU JEEVITHA
SVIMS, Tirupati
Outcome results
None listed