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To determine the efficacy between time dependent vs volume dependent chest tube drainage removal protocol following talc slurry pleurodesis in malignant pleural effusion - A randomized control trial

A randomized control trial to study the efficacy of time dependent versus volume dependent chest drain removal protocol for TALC slurry pleurodesis in patients with malignant pleural effusion. - TIMEVOL

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/07/026652
Enrollment
100
Registered
2020-07-17
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-D49- Neoplasms

Interventions

Intervention1: Time dependent arm - Chest tube removal at 12 hours post pleurodesis: In all biopsy proven malignancy, post pleurodesis - all chest tubes will be removed at 12 hours. Control Interventi

Sponsors

Christian Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age more than 18 years with biopsy/cytology proven malignant pleural effusion and planned for TALC pleurodesis

Exclusion criteria

Exclusion criteria: 1.Patients who do not give informed consent 2.Expected survival period of less than 2 months 3.Patient with earlier pleurodesis failure 4.Evidence of trapped lung following drainage of pleural fluid- Trapped lung defined as evidence of failed re-expansion of the lung after pleural fluid drainage and confirmed by chest X-ray 5.Ipsilateral endobronchial obstruction

Design outcomes

Primary

MeasureTime frame
Efficacy of Pleurodesis in two different chest drain removal protocols (volume versus time based chest drain removal protocols)Timepoint: Sucess of pleurodesis will be assessed at the end of 7days, 1month and 3 months.

Secondary

MeasureTime frame
To compare the duration of hospital stay in two arms following talc pleurodesisTimepoint: Will be assessed only once at the end of hospital stay;To compare complications and Mortality in two arms Timepoint: Complications and mortailty will be assessed at the end of 7days, 1month and 3 months.

Countries

India

Contacts

Public ContactSarah Ann Koshy

CHRISTIAN MEDICAL COLLEGE

drricha21@gmail.com04162282859

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026