Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Injection Methylprednisolone: 1 mg/kg Intravenous once a day for 3 days
Control Intervention1: Injection Dexamethasone: 6 mg intravenous once a day for 3 days
Sponsors
Dr Ananthakumar P K
Eligibility
Inclusion criteria
Inclusion criteria: Age more than 18 years old Both sex Lab. Confirmed COVID-19 cases with ARDS
Exclusion criteria
Exclusion criteria: Mild and moderate COVID-19 Severe immunosuppression (HIV infection, long-term use of immunosuppressive agents Pregnant or lactating women Patients already on steroids Patients with High Procalcitonin level
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcomes: Difference in IL-6 level from baseline. Days to ventilator liberation Length of hospital stay (LOS). In-hospital all-cause mortality. The secondary outcomes Time to fever resolution Levels of bio-markers (CRP, D dimer, Ferritin) on Day 1 and Day 3. Timepoint: Day 1 and Day 3 for IL-6 level | — |
Secondary
| Measure | Time frame |
|---|---|
| patient details like baseline demographic data, laboratory reports â?? lymphocyte count, CRP, procalcitonin, Ferritin, D-dimer and clinical parameters including length of hospital stay and days in ventilator will be recorded before and after treatment with dexamethasone/methylprednisolone. Timepoint: from day 1 to day 3 for variation in CRP ferritin | — |
Countries
India
Contacts
Public ContactDr Ananthakumar P K
Chettinad Academy of Research and Education
Outcome results
None listed