To compare the effects of two different doses of the drug Magnesium Sulphate when added to the drug Ropivacaine of 0.5% concentration in the block above the clavical in upper limb surgery

COMPARATIVE STUDY OF TWO DIFFERENT DOSES OF MAGNESIUM SULPHATE AS AN ADJUVANT TO 0.5% ROPIVACAINE IN SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK IN ELECTIVE UPPER LIMB ORTHOPAEDIC SURGERY:A RANDOMISED STUDY

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/07/026549

Enrollment

Registered

2020-07-14

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R298- Other symptoms and signs involvingthe nervous and musculoskeletal systems

Interventions

Intervention1: Injection Magnesium Sulphate 250 mg: Injection Magnesium Sulphate 250 mg 1 ml given with 30 ml of Injection 0.5% Ropivacaine hydrochloride as an adjuvant given as a single dose in Perip

Eligibility

Inclusion criteria

Inclusion criteria: 1. American society of Anaesthesiology physical status 1 and 2 2. Scheduled for elective upper limb orthopaedic surgery(forearm and elbow surgery) 3. Informed and written consent to the study

Exclusion criteria

Exclusion criteria: 1. Patient with known hypersensitivity to LA 2. Local infection at the site of the block 3. Patients with known coagulopathy or on anticoagulation therapy 4. Patients with history of cardiac,hepatic,renal disease,respiratory,neurological,psychiatric,neuromuscular disorders 5. Pregnant and lactating patients 6. Patients with morbid obesity 7. Patients with systemic use of corticosteroids for 2 weeks or longer within 6 months of surgery and chronic opioid use 8. Patients who are unable to comprehend the Visual Analogue Scale(VAS)for pain assessment

Design outcomes

Primary

Measure	Time frame
To compare the duration of analgesia between patients receiving supraclavicular block with Ropivacaine 0.5% +Magnesium Sulphate(150mg) versus Ropivacaine 0.5%+Magnesium Sulphate(250mg)Timepoint: From the time of completion of block to the demand of first rescue analgesic in the postoperative period	—

Secondary

Measure	Time frame
To compare the onset of sensory and motor block, the duration of sensory and motor blockade and total rescue analgesic requirements.Timepoint: Onset of sensory blockade-time interval between end of injection and loss of pinprick response Onset of motor blockade-time interval between end of injection and complete motor paralysis of wrist and hand. Duration of sensory blockade-interval between sensory blockade and reappearance of pinprick response Duration of motor blockade-time interval between maximum motor blockade and complete movement of wrist and fingers. Total rescue analgesic requirement in first 24 post operative hours	—

Measure

Time frame

To compare the onset of sensory and motor block, the duration of sensory and motor blockade and total rescue analgesic requirements.Timepoint: Onset of sensory blockade-time interval between end of injection and loss of pinprick response Onset of motor blockade-time interval between end of injection and complete motor paralysis of wrist and hand. Duration of sensory blockade-interval between sensory blockade and reappearance of pinprick response Duration of motor blockade-time interval between maximum motor blockade and complete movement of wrist and fingers. Total rescue analgesic requirement in first 24 post operative hours

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Countries

India

Contacts

Public ContactDr Tejwant Rajkhowa

Gauhati Medical College and Hospital

pammy.baber@gmail.com9864062992

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026