Health Condition 1: I249- Acute ischemic heart disease, unspecified
Conditions
Interventions
Intervention1: Remote ischemic conditioning: RIC will be done by four alternating cycles of 5-minute inflation of standard upper arm blood pressure cuff to 200 mmHg (or 40mmHg above the individual’s s
Sponsors
Indian council of medical research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age = 18 years 2. Awaiting percutaneous coronary intervention (PCI) 3. Serum creatinine of >1.4 mg/dl or an estimated glomerular filtration rate (eGFR) of
Exclusion criteria
Exclusion criteria: 1. Patients on hemodialysis/peritoneal dialysis 2. Recent intravascular contrast exposure (= 2 weeks prior to present admission) 3. Inability to perform remote ischaemic conditioning (RIC) (e.g., bilateral upper limb trauma/amputation, severe ischaemia etc) 4. Pregnancy 5. Hypotension (MAP 6. Sepsis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary end-point: Incidence of CINTimepoint: At 48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of subclinical AKI 2. Change in serum creatinine from baseline to 48 hours post-PCI (?creat) 3. Change in NGAL levels from baseline to 2 hours post-PCI (?NGAL2) and to 6 hours post-PCI(?NGAL6) 4. Need for renal replacement therapy 5. In-hospital-, 30- and 90-day all-cause mortality and major adverse cardiovascular events (MACE) Timepoint: 1. Change in NGAL at 2- and 6-hours post-PCI 2. Incidence of subclinical AKI and change in creatinine at 24- and 48- hours post_PCI 3. In-hospital, 30- and 90- day all cause mortality and MACE | — |
Countries
India
Contacts
Public ContactINDU RAMACHANDRA RAO
KASTURBA MEDICAL COLLEGE
Outcome results
None listed