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Comparison of pain relief after surgery using three pain-killer medications (morphine, clonidine, dexmedetomidine) along with local anaesthetic in children undergoing surgery in the lower abdomen and legs under general anaesthesia

Double Blinded Randomized control trial to compare duration of analgesia by using Morphine, Clonidine or Dexmedetomidine as adjuvants to ropivacaine in caudal anaesthesia in children undergoing infra-umbilical surgeries.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/07/026481
Enrollment
60
Registered
2020-07-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N399- Disorder of urinary system, unspecified

Interventions

Intervention1: three intervention arms for adjuvants to caudal anaesthesia. First arm used morphine as adjuvant. Second arm used clonidine as adjuvant and third arm used dexmedetomidine as adjuvant to

Sponsors

Fluid Research Grant Christian Medical College Vellore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All children between 1 and 6 years of age posted for elective infra umbilical surgeries

Exclusion criteria

Exclusion criteria: Study exclusion criteria includes children with a history of developmental delay or mental retardation, a known or suspected coagulopathy; a known allergy to any of the study drugs; and any signs of infection at the site of the proposed caudal block, emergency surgery,ASA 3 or 4,Preop gcs <14/15.

Design outcomes

Primary

MeasureTime frame
To compare the duration of post operative analgesia with caudal Morphine,or Clonidine, or Dexmedetomidine in children undergoing infra umbilical surgeries. Timepoint: on arrival in post anaesthesia care unit (PACU), 15 minutes, 30 minutes, 1 hour and 2 hours time points in the PACU. On arrival in the ward: 0 hour, 1 hour, 2 hour, 6 hour, 10 hour, 14 hour, 18 hour and 24 hours after arrival in ward.—

Secondary

MeasureTime frame
To study the number of doses of analgesic required during first 24 hours.Timepoint: First 24 hours after surgery.—

Countries

India

Contacts

Public ContactAparanjit Paul Pallapati

Christian Medical College,Vellore.

aparanjitpaul@gmail.com00919894462310

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026