Comparing the usefulness of two drugs in providing relief for swelling and pain after surgical removal of lower third molar teeth.

COMPARISON OF EFFECTIVENESS OF BROMELAIN WITH DICLOFENAC SODIUM IN THE MANAGEMENT OF POSTOPERATIVE SWELLING AND PAIN FOLLOWING MANDIBULAR THIRD MOLAR SURGERY-A CROSSOVER TRIAL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/07/026443

Enrollment

Registered

2020-07-09

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z488- Encounter for other specified postprocedural aftercare

Interventions

Intervention1: Drug-Diclofenac sodium: Dose-50 mg tablet Frequency-Thrice daily Route of Administration-Oral Duration-5 days Intervention2: Drug- Bromelain: Dose-500 mg Capsule Frequency-Twice daily

Eligibility

Inclusion criteria

Inclusion criteria: Patients with bilateral impacted mandibular third molars diagnosed for surgical extraction.

Exclusion criteria

Exclusion criteria: 1.Pregnant and lactating women 2.Patients on anticoagulant therapy 3.Patients allergic to bromelain or Diclofenac Sodium 4.Use of any antibiotic or anti-inflammatory drug within 2 weeks of study entry 5.Patients with history of peptic ulcer disease/GI bleed

Design outcomes

Primary

Measure	Time frame
SwellingTimepoint: To measure swelling on the 1st 2nd and 7th post operative days.	—

Secondary

Measure	Time frame
Inter incisal mouth openingTimepoint: To measure the Inter incisal mouth opening on the 1st 2nd and 7th post operative days.;PainTimepoint: To measure pain on the 1st 2nd and 7th post operative days.	—

Countries

India

Contacts

Public ContactVidya Rattan

Post Graduate Institute of Medical Education and Research, Chandigarh, India

drvidyarattan@gmail.com9914900871

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026