Health Condition 1: F422- Mixed obsessional thoughts and acts Health Condition 2: F429- Obsessive-compulsive disorder, unspecified Health Condition 3: F428- Other obsessive-compulsive disorder
Conditions
Interventions
Intervention1: Deep trans cranial magnetic stimulation (dTMS): High frequency(20 Hz) dTMS is given for 10 sessions. Each session includes 50 trains of 2 second duration with inter-train interval of 20
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Obsessive-Compulsive Disorder using Diagnostic Criteria for Research (DCR) of ICD 10 DCR (WHO, 1993) 2. Y-BOCS score of 15 or above 3. Age between 18-60 years of either sex 4. Right-handed 5. Educational qualification of class VIII and above 6. Patients giving written informed consent
Exclusion criteria
Exclusion criteria: 1. Co-morbid severe depression as measured by a HAM-D score of 23 or more 2. Patients with co-morbid neurological or any other psychiatric disorder 3. Patients who cannot undergo MRI scan 4. Colour blind, as indicated by Ishiharaâ??s charts
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome of the study is the clinical improvement in patients with OCD as recorded on Y-BOCS scale as seen at the end of 2 weeks of high frequency dTMS treatment.Timepoint: 1. At baseline 2. Day 1 (after 1st session of dTMS/sham stimulation ) 3. Day 14 (at the end of 10 sessions of stimulation) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are the changes in functional activation of ACC and mPFC as measured by resting state fMRI and Stroop task evoked fMRI following 10 session of high frequency dTMS in patients with OCD.Timepoint: 1. At baseline 2. Day 1 (after 1st session of dTMS/Sham stimulation ) 3. Day 14 (at the end of 10 sessions of stimulation ) | — |
Countries
India
Contacts
Public ContactSachin Reddy KR
Central Institute of Psychiatry, Ranchi
Outcome results
None listed