Health Condition 1: K769- Liver disease, unspecified
Conditions
Interventions
Intervention1: Midodrine: Dose: Midodrine 10 mg
Route of Administration:Oral Frequency: Once Daily
Duration: One time only
Control Intervention1: Not Applicable: Not Applicable
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) CLD with grade III ascites with Na less than 130, Systolic BP less than 90 and type 2 HRS. 2) ACLF (APASL criteria) with Na less than 130, Systolic BP less than 90 and AKI.
Exclusion criteria
Exclusion criteria: 1) age 75, 2) Pregnancy, 3) Splanchnic venous thrombosis, 4) Hepatocellular Carcinoma, 5) Hepaticencephalopathy, 6) Significant cardiopulmonary disease, 7) Uncontrolled diabetes, 8) Hypertension, 9) Intrinsic renal disease, 10) Peripheral vascular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HVPG response after administration of midodrine as defined by decrease in HVPG by 20 % from baseline or less than equals to 12 mmHg.Timepoint: 3 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in HVPG, SVR, heart rate, cardiac output, cardiac index, Blood pressure (systolic, diastolic and mean).Timepoint: 3 hours | — |
Countries
India
Contacts
Public ContactDr Chitranshu Vashishtha
Institute of Liver and Biliary Sciences
Outcome results
None listed