Health Condition 1: I050- Rheumatic mitral stenosis
Conditions
Interventions
Intervention1: Ivabradine: 5 mg twice daily for 6 months
Control Intervention1: Metoprolol: Metoprolol 50 mg once daily 6 month
Sponsors
VIMSAR
Eligibility
Inclusion criteria
Inclusion criteria: Age >=18 yrs. Documented/newly diagnosed mitral stenosis Normal sinus rhythm (heart rate not less than 70 bpm)
Exclusion criteria
Exclusion criteria: Unable to perform treadmill test (TMT)/contraindication for TMT/ Very severe MS in urgent need for surgical treatment Other significant valvular lesions (more than mild aortic stenosis/aortic regurgitation/ mitral regurgitation/Tricuspid regurgitation/Tricuspid stenosis) o Presence of significant noncardiac comorbidities, e.g., chronic obstructive pulmonary disease, renal failure, malignancy, etc. RHD with Pregnancy Known allergy/intolerance to study drugs known coronary artery disease, cardiomyopathies, congenital heart diseases, HTN etc. LVEF less than 40% Marked anaemia (Hb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the efficacy of Ivabradine to Beta-blockers in terms of subjective and objective (clinical and hemodynamic and exercise) parameters between two groups.Timepoint: 6 months from reruitment | — |
Secondary
| Measure | Time frame |
|---|---|
| safety data-to document any adverse drug reactions related to drug ivabradine.Timepoint: 6months | — |
Countries
India
Contacts
Public ContactDr Ayan Roy
Associate professor
Outcome results
None listed