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A Study to evaluate the effect of premedication with oral pregabalin in attenuating the hemodynamic pressor response to laryngoscopy and intubation

An Evaluation Of The Effect Of Premedication With Oral Pregabalin In Attenuating The Pressor Response To Laryngoscopy And Intubation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/07/026382
Enrollment
64
Registered
2020-07-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: premedication: premedication with tablet pregabalin 150 mg 90 minutes before surgery Control Intervention1: placebo: vitamin b complex tablet 90 minutes before surgery

Sponsors

St Stephens Hospital DELHI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective surgery under general anesthesia, requiring tracheal intubation.

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Seizure disorders 3.Patients on chronic neuroleptic medications, tricyclic antidepressants or serotonin and nor epinephrine re-uptake inhibitor 4. Pregnant or breast-feeding women. 5. Anticipated difficult airway. 6. History of cardiac, pulmonary, or renal disease, Uncontrolled Diabetes or hypertension. 7. GI disturbance which hinders enteric absorption to oral medications. 8. Allergy to any anaesthetic medication and Pregabalin. 9. Duration of laryngoscopy exceeding 25 seconds or second attempt for intubation is needed. 10. Mallampati grade 3 and 4

Design outcomes

Secondary

MeasureTime frame
sedationTimepoint: 90 minutes—

Primary

MeasureTime frame
attenuates the pressor response to laryngoscopy and intubationTimepoint: 15 minutes—

Countries

India

Contacts

Public ContactInderpreet Singh Walia

st stephens hospital delhi

drfarhat@rediffmail.com9810162940

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026