A study to evaluate the effect of dexmedetomidine on blood pressure and heart rate of patients during a surgical procedure where pins are drilled inside the skull while removing a part of it.

The effect of dexmedetomidine vs placebo on haemodynamic response to skull pin insertion in patients undergoing craniotomy:a randomised blinded comparative study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/07/026325

Enrollment

Registered

2020-07-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems

Interventions

Intervention1: Dexmedetomidine Hydrochloride: Inj dexmedetomidine hydrochloride at the dose of 1microgram per kg bodyweight given intravenous using a syringe pump over 10 mins before induction of anae

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA I and II 2.Elective surgery 3.Pre operative GCS 15 4.Patients giving valid consent

Exclusion criteria

Exclusion criteria: 1.Pre operative heart rate less than 45 2.Pregnancy 3.Known allergy to dexmedetomidine 4.Second or third degree haeart block

Design outcomes

Primary

Measure	Time frame
To determine the effect of iv inj dexmedetomidine in attenuating the haemodynamic response(SBP,DBP,MAP,HR) to skull pin holder application during craniotomyTimepoint: At the time of pin insertion,1,5,10,15 mins after pin insertion	—

Secondary

Measure	Time frame
To compare the plasma glucose level before and after pin insertionTimepoint: 15 mins before the administration of inj dexmedetomidine or placebo(baseline) and 30 and 60 mins after pin insertion;To determine the effect of iv inj dexmedetomidine in attenuating the haemodynamic response(SBP,DBP,MAP,HR) during laryngoscopy and intubation Timepoint: After giving drug or placebo,after intubation	—

Countries

India

Contacts

Public ContactDr Nandini Phukan

Gauhati Medical College and Hospital

faizaahmedtalukdar@gmail.com9864031429

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026