Health Condition 1: A638- Other specified predominantly sexually transmitted diseases
Conditions
Interventions
None listed
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Oral Potentially Malignant Disorders (OPMD) Clinically and histologically confirmed cases of OPMDs would be prospectively recruited for this study. Subjects willing to participate in the study Controls (Approximately Age and sex matched to OPMDs groups) Subjects willing to participate in the study Subjects with normal mucosa( absence of any OPMDs and OSCC)
Exclusion criteria
Exclusion criteria: Subjects with history of significant and serious uncontrolled systemic disease. Subjects with history / treatment ( past / current)of any other malignant disease Subjects with history of any (past/ current) HPV related malignancy at any site in their spouses / partners Subjects with history of HPV vaccination Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Molecular biomarkers to determine risk for malignant transformation. Non â?? invasive method of oral scrapings as a screening tool for persistent HPV detection in OPMDs.Timepoint: after 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| The prevalence of current and persistent HPV infection in common OPMDs if found to be significant can strengthen the case for advocacy for safe sexual practices, risk-adapted screening strategies, differentiated follow- up and HPV vaccination to prevent HPV related cancers in oral and other sites.Timepoint: after 3 years | — |
Countries
India
Contacts
Public ContactDr Shalini Gupta
Centre for Dental Education and Research AIIMS New Delhi
Outcome results
None listed