Health Condition 1: D519- Vitamin B12 deficiency anemia, unspecified
Conditions
Interventions
Intervention1: Oral Vitamin B12: Arm A: Oral vitamin B12
1500 microgram orally once a day
for 4 weeks
Control Intervention1: Intravenous Vitamin B12: Arm B: Vitamin B12
1000 microgram IV weekly
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Sponsors
CMC Ludhiana
Eligibility
Inclusion criteria
Inclusion criteria: 1. Anemia as per WHO definition 2. Above 18 years of age 3. Low vitamin B12 level (below 250 pg/ml) 4. With or without symptoms or signs of vitamin B12 deficiency (except severe neurological symptoms)
Exclusion criteria
Exclusion criteria: Refusal to consent for the study 2. Hemoglobin level below 5 g/dl or Platelet count below 20000/mm3 3. Patients with ongoing oral vitamin B12 supplement 4. Documented pernicious anemia or malabsorption disorders 5. Serious neurological or psychiatric symptoms 6. Surgery or diseases affecting the jejunum-ileum 7. Hypersensitivity to vitamin B12 or any vitamin preparations 8. Pregnant females with vitamin B12 deficiency 9. Serum Folic acid less than 2.3 ng/ml 10. Stage IV Kidney disease 11. Already involved in any other ongoing trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To check vitamin B12 level at 5th week post initiation of treatment.Timepoint: To check vitamin B12 level at 5th week post initiation of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Haemoglobin level, MCV, reticulocyte count 2. To analyse the cost difference 3. Improvement in signs and symptoms present at the time of diagnosis. Timepoint: 5 weeks | — |
Countries
India
Contacts
Public ContactKetan Modak
CMC Ludhiana
Outcome results
None listed