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Comparing effectiveness of anti-emetic drugs (palonosetron and dexamethasone), in preventing nausea and vomiting in postoperative period, in patients undergoing laparoscopic surgeries.

Comparative efficacy of palonosetron-dexamethasone combination, palonosetron or dexamethasone alone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgeries.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/06/026213
Enrollment
120
Registered
2020-06-29
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R110- Nausea Health Condition 2: R112- Nausea with vomiting, unspecified Health Condition 3: R111- Vomiting

Interventions

None listed

Sponsors

Kasturba Medical College Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists physical status I & II, Patients scheduled for elective laparoscopic procedures under general anaesthesia, Body Mass Index 15 ââ?¬â?? 24.9 kg/m2

Exclusion criteria

Exclusion criteria: Pregnant women Patients with history of motion sickness Patients with history of long term opioid use Patients in whom antiemetic medications were administered less than 24 hours prior to surgery

Design outcomes

Primary

MeasureTime frame
Comparative incidence of postoperative nausea and vomiting in patients undergoing laparoscopic procedures who have been administered palonosetron -dexamethasone combination, palonosetron or dexamethasone.Timepoint: Immediately after shifting to post-anaesthesia care unit 1 hour after extubation, 2 hours after extubation, 4 hours after extubation, 6 hours afterextbation, 12 hours after extubation 24 hours after extubation—

Secondary

MeasureTime frame
Need for use of an additional anti-emetic in the postoperarive period.Timepoint: Immediately after shifting to post-anaesthesia care unit 1 hour after extubation, 2 hours after extubation, 4 hours after extubation, 6 hours afterextbation, 12 hours after extubation 24 hours after extubation—

Countries

India

Contacts

Public ContactMICHELLE RAPHAEL

Kasturba Medical College, Manipal

arunhd2000@yahoo.com9008415858

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026