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Study of HOX gene expression in Mouth Cancer

Epithelial Reprograming of HOX Genes by Epigenetic Mechanisms and its implication to Oral Cancers

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/06/026202
Enrollment
125
Registered
2020-06-29
Start date
Unknown
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx

Interventions

None listed

Sponsors

The Wellcome Trust DBT India Alliance
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Newly diagnosed cases of premalignant lesions, Oral cancer with specific Stage as per TNM staging and normal tissues

Exclusion criteria

Exclusion criteria: Patients with recurrence of oral cancer and on treatment

Design outcomes

Primary

MeasureTime frame
to determine the role of HOX gene methylation and their targets in OC tissues and in 3-dimensional tissue reconstructs as validation models to determine the mechanisms and identify potential therapeutic targets.Timepoint: 1st year, 2nd year 3rd year—

Secondary

MeasureTime frame
Identification of prognostic molecular markers for oral cancerTimepoint: 4th year, 5th year—

Countries

India

Contacts

Public ContactKanaka Sairam Padam

Manipal College of Dental Sciences

raghu.ar@manipal.edu

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026