Comparing the efficacy of using the biological solution of Plasma Rich in Platelets combined with Growth Hormone Vs only PRP in Early Knee Osteoarthritis and to assess the functional improvement

Comparing the Efficacy of Intra articular Growth Hormone and Platelet Rich Plasma(PRP) Vs Intra articular Platelet Rich Plasma alone and to study their effects on Articular cartilage thickness in Knee Osteoarthritis.

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/06/026167

Enrollment

Registered

2020-06-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Intra Articular Knee Joint Injection Under Musculoskeletal Ultrasound Guidance: 2 doses of Intra Articular Platelet Rich Plasma+Growth Hormone in Grade 1 AND 2 Knee Osteoarthritis at 4

Eligibility

Inclusion criteria

Inclusion criteria: Age: >40 years Symptoms > 3 months Both sexes Grade I and II osteoarthritis knee by kellgren-lawrence grading Knee pain unresponsive to conservative treatment for 1 month Stiffness: Crepitus + Bony tenderness+ Bony enlargement+ No palpable warmth

Exclusion criteria

Exclusion criteria: Cellulitis / Bursitis/AcuteInfections Polyarticular disease Steroid injection in the last 3 months. Any implants inside. Trauma Meniscal injury/Ligament Injury Rheumatoid arthritis/Gouty arthritis Cancer/ Malignant lesions. Hemophilia Use of anticoagulants and NSAIDS for past 7 days

Design outcomes

Primary

Measure	Time frame
1)Pain Relief- Compared as per visual Pain Analogue scores 2)Functional outcomes â?? Knee pain, stiffness and physical function are studied through WOMAC Osteoarthritis Index 3) Articular Cartilage Thickness â?? measured with musculoskeletal ultrasound Timepoint: Baseline 4 Weeks 8 Weeks	—

Secondary

Measure	Time frame
Functional Improvement in Knee range of motion, enhanced quality of life, increased self dependency and painless ambulationTimepoint: 8 weeks	—

Countries

India

Contacts

Public ContactDR P Thirunavukkarasu

Govt Kilpauk Medical College

padmarani795@gmail.com7598598903

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026