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study of comparison of changes in the hemodynamic responses to laryngoscopy and intubation after giving intravenous esmolol and diltiazem in elective surgeries under general anesthesia. It is a randomised double blind interventional study conducted at SMS hospital, jaipur

A Comparative Study of Intravenous Esmolol Versus Diltiazem for Attenuation of Hemodynamic Responses To Laryngoscopy and Intubation in Elective Surgeries under General Anaesthesia: A Randomized Double Blind Interventional Study at SMS Hospital Jaipur During Year 2019-20.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/06/026148
Enrollment
96
Registered
2020-06-25
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: INJECTION ESMOLOL IV: 48 Patients will receive injection Esmolol 0.5mg/kg IV, diluted with normal saline to make total volume to 10ml and given as single IV bolus injection 5minutes aft

Sponsors

Department of anesthesiologySMS Medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients willing to give informed written consent 2. Patients with ASA grade 1 and 2 3. Age group-20-50 years 4. Patients scheduled for elective surgeries under general anesthesia with larnygoscopy and endotracheal intubation

Exclusion criteria

Exclusion criteria: 1. Patients unwilling to participate in the study. 2. Patients with difficult airway i.e more than 1 attempt of intubation performed or more than 15 seconds intubation time taken. 3. Patients having known allergy to the drugs used in the study. 4. Patients with history of any medications affecting heart rate and blood pressure. 5. Patients with history of any severe cardiovascular, respiratory, endocrine, renal,hepatic, neurotic or psychiatric illness . 6. Patients with baseline heart rate 7. Patients with ASA grade -3,4,5. 8. Patients with bleeding disorders.

Design outcomes

Primary

MeasureTime frame
To assess and compare changes in Hemodynamic parameters- Heart rate, Systolic blood pressure,Diastolic blood pressure, Mean arterial blood pressure in both the study groups Timepoint: baseline values, after test drugs, before laryngoscopy, 1minute, 3minutes, 5minutes, 10minutes after intubation—

Secondary

MeasureTime frame
To look for any side effects- hypotension, bradycardia, headache, flushing or any other complaint in both the study groupsTimepoint: 1hour, 6hours, 12hours and 24 hours post operatively—

Countries

India

Contacts

Public ContactDR SARITA KUMARI

SMS Medical college

rajnimathur@hotmail.com829357194

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026