An interventional trial of ENALAPRIL MALEATE for PREVENTION OF OVARIAN HYPERSTIMULATION SYNDROME

Enalapril maleate for prevention of Ovarian Hyperstimulation Syndrome â?? A before after single arm experimental study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/06/026143

Enrollment

Registered

2020-06-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N979- Female infertility, unspecified

Interventions

Intervention1: Tab Enalapril Maleate 2.5 mg by vaginal route from Day 2 of ovum pick up till Day 7: ACE Inhibitor decreases the ovarian VEGF expression and vascular permeability and thus reduce the in

Eligibility

Inclusion criteria

Inclusion criteria: (i) Women with PCOS undergoing assisted conception, having more than 4 follicles at the time of hCG or LH trigger (ii) Women undergoing assisted conception, expected to have more than 16 oocytes retrieval. (iii) Women with known PCOS, both lean and obese. (iv) Women with previous history of OHSS (v) High responders (vi) Women with S.estradiol levels > 5000pg/ml, on the day of trigger

Exclusion criteria

Exclusion criteria: Exclusion criteria would include women with androgen secreting tumors

Design outcomes

Primary

Measure	Time frame
Prevention of OHSSTimepoint: 2 weeks	—

Secondary

Measure	Time frame
NILTimepoint: NOT APPLICABLE	—

Countries

India

Contacts

Public ContactShilpa Bajpai

INHS Asvini

drshilpa_afmc85@yahoo.co.in8454912481

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026