Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: J128- Other viral pneumonia
Conditions
Interventions
Intervention1: Convalescent plasma: Anti SARS COV 2 convalescent plasma viral neutralizing antibodies blood product two doses of 200 ml transfusion 24 hours apart
Control Intervention1: Standard of Ca
Sponsors
Dr Sushant Meshram
Eligibility
Inclusion criteria
Inclusion criteria: Hospitalized COVID-19 patients, Fever Cough breathlessness plus one or more of the following respiratory rate more than 30 per minutes, O2 saturation less than 90%, PaO2 by FiO2 less than 300. Patients with Comorbidities Viz.DM,COPD,HTN,Asthma included.
Exclusion criteria
Exclusion criteria: Pregnant and Breast Feeding Females, Critically ill patients viz. Severe ARDS,Sepsis,Septic shock MODS,Coronary artery disease,arrhythmia Heart Failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients showing at least 2 points clinical improvement on WHO ordinal scale at 28 days post randomization. All cause mortality at 28 daysTimepoint: 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to clinical improvement. Length of hospital stay. Change in SOFA score. Duration of oxygen support. Duration of respiratory support required. Levels of biomarkers CRP Ferritin,D Dimer pre and posttransfusion. Radiological improvement. Timepoint: 28 days | — |
Countries
India
Contacts
Public ContactDr Sushant Meshram
government medical college and hospital Nagpur
Outcome results
None listed