Role of oral dextromethorphan in relieving cough during flexible bronchoscopy

Role of dextromethorphan premedication versus placebo in alleviation of cough during flexible bronchoscopy in adults: A randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/06/026115

Enrollment

Registered

2020-06-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J40- Bronchitis, not specified as acuteor chronic

Interventions

Intervention1: Dextromethorphan premedication: Intervention group will receive 30 mL (90mg) of dextromethorphan syrup 60 minutes before the bronchoscopy Control Intervention1: Placebo syrup: placebo g

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged >=18 years and <=70 years who required diagnostic bronchoscopy for any valid indication

Exclusion criteria

Exclusion criteria: a. Lack of informed consent. b. Profound refractory hypoxemia. c. Severe bleeding diathesis. d. Recent myocardial infarction or unstable angina. e. Respiratory failure. f. Uncontrolled hypertension. g. Unstable cardiac arrhythmias. h. Pregnant or lactating women. i. Renal failure. j. Use of sedatives or centrally acting drugs 12 hours prior to bronchoscopy. k. Patient taking Monoamine Oxidase inhibitors or serotonergic agents. l. History of hypersensitivity to dextromethorphan

Design outcomes

Primary

Measure	Time frame
A. To assess the effect of oral dextromethorphan premedication on severity of cough during bronchoscopyTimepoint: 0 and 1 hour	—

Secondary

Measure	Time frame
1. To evaluate the impact of dextromethorphan premedication on requirement of sedative used during flexible bronchoscopy 2. To assess the effect of dextromethorphan premedication on quantity of topical anaesthetics used during the procedure. Timepoint: 0 hour	—

Countries

India

Contacts

Public ContactAnanda Datta

All India Institute of Medical Sciences

pulmed_manoj@aiimsbhubaneswar.edu.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026