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doxycycline in treatment of fungal corneal ulcer

A randomised controlled trial to evaluate the role of oral doxycycline in the treatment of fungal keratitis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/06/026097
Enrollment
300
Registered
2020-06-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: doxycycline 100 mg: oral doxycycline 100 mg bd for 15 days in study arm Control Intervention1: placebo drug: placebo drug bd for 15 days in control arm

Sponsors

srikiran institute of ophthalmology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: fungal corneal ulcers measuring less than 7 mm in largest dimension and upto mid stromal involvement

Exclusion criteria

Exclusion criteria: children less than 20 years of age, adults more than 75 years of age, pregnant and lactating women, one eyed, perforated ulcers, ulcers with more than 7mm size in largest dimension

Design outcomes

Primary

MeasureTime frame
healing of epithelial defect, resolution of ulcer, rate of perforation, requirement for TPKTimepoint: at presentation, 1 week, 2 weeks, 3 weeks, 4 weeks

Secondary

MeasureTime frame
TPK conversionTimepoint: 3 weeks

Countries

India

Contacts

Public Contactmadhu uddaraju

srikiran eye hospital

eyedrmadhu@gmail.com9676743333

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026