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To compare the safety parameters of two different modes of a corneal strengthening procedure in patients with Keratoconus.

Comparison of efficacy and efficiency of continuous v/s pulsed modes of corneal collagen cross linking in keratoconus

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/06/026093
Enrollment
50
Registered
2020-06-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H186- Keratoconus

Interventions

Intervention1: PULSED MODE ACCELERATED CXL: In pulsed light accelerated corneal collagen crosslinking (pl-ACXL) 8 minutes (1.5â??sec. on/1.5â??sec. off) of UV-A exposure at 30â??mW/cm2 with an energy

Sponsors

Nethradhama Superspeciality Eye Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients giving written informed consent. 2. Patients within age group of 10-40yrs. 3. Patients with progressive keratoconus. 4. Patients with pre-operative corneal thickness measured with pachymetry of more than 400microns.

Exclusion criteria

Exclusion criteria: 1. corneal pachymetry less than 400 microns 2. decompensated cornea 3. corneal dystrophies 4. age > 40years and 5. pre-existing scar 6. severe dry eye 7. eyes with limbal stem cell deficiency. 8. corneal ectasia other thankeratoconus. 9. active ocular surface disorder.

Design outcomes

Primary

MeasureTime frame
To compare the efficacy and safety of continuous and pulsed mode of corneal collagen cross linking for keratoconus patients.Timepoint: Relevant data will be collected preoperatively , at 1, 3, 6 months postoperatively.

Secondary

MeasureTime frame
1. Pre operative and post operative Uncorrected and best corrected visual acuity 2. Pre operative and post operative changes in corneal parameters 3. Pre operative and post operative changes in corneal thickness. 4. To assess the depth of stromal demarcation line following treatment Timepoint: Relevant data will be collected preoperatively , at 1, 3, 6 months postoperatively.

Countries

India

Contacts

Public ContactDR Kriti Mehrotra

Nethradhama Superspeciality Eye Hospital

namita589@yahoo.co.in9845370131

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026