Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine: dose - 0.5mcg/kg intravenous bolus , followed by 0.5mcg/kg/hour till the start of skin closure
Control Intervention1: placebo: equal dose as compared to dexmedetomidine
Sponsors
Indraprastha Apollo Hospital New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Patients with American Society of Anesthesiologists (ASA) physical status I-III aged 60- 80 years old, undergoing elective lumbar spine surgery
Exclusion criteria
Exclusion criteria: 1. Patients age less than 60 years and more than 80 years old. 2. Patients with a pre-operative or intraoperative ECG (electrocardiogram) that showed severe bradycardia (sinus rhythm, heart rate less than 50/ min) or conduction block 3. Patients with associated renal, hepatic and respiratory dysfunction. 4. Patients with history of central nervous system disease such as head injury, stroke, previous neurosurgery, behavioral disturbances or mental retardation. 5. Patients with preoperative cognitive dysfunction (MMSE 6. Patients on β-blockers, cimetidine, digoxin, α2-agonists, anticonvulsants or psychotropic medications 7. Patients with allergy to dexmedetomidine or another alpha-2 adrenergic receptor agonist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Mini- Mental State Examination (MMSE) Scores. 2. 15-item quality of recovery score (QoR15) questionnaire. Timepoint: 1. Before Anaesthesia 2. Day 1 of Surgery 3. Day 2 of Surgery 4. Day 3 of Surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Intraoperative propofol consumption. 2. Intraoperative and postoperative fentanyl requirement. 3. Haemodynamic changes Timepoint: till the duration of surgery | — |
Countries
India
Contacts
Public ContactDr K J Choudhury
Indraprastha Apollo Hospital
Outcome results
None listed