Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention1: Intermittent Fasting: Intermittent fasting or time restricted eating after sunrise approximately 6 am and between sunset approx 6 pm and daily 12 hours night fasting and one a day in 15
Sponsors
Rohit Walia
Eligibility
Inclusion criteria
Inclusion criteria: Age 40 to 60 years males Stable Coronary artery disease patients referred for percutaneous intervention in an artery suitable for intravascular ultrasound pullback Non diabetic Non Smokers Left ventricular ejection fraction greater than 45 percent Body mass index greater than 25
Exclusion criteria
Exclusion criteria: Left main disease More than moderate left ventricular systolic dysfunction ( LVEF Deranged Renal Function Test Chronic Liver Disease Advanced Malignancy Severe chronic obstructive pulmonary disease Any addiction Not willing to give consent Hypothyroid or hyperthyroid disorders Body mass index Infectious diseases Peptic ulcer Bleeding disorder Need for coronary artery bypass grafting Hemodynamically unstable patients Gout Celiac disease Anemia Specific Food allergy Failure to advance IVUS catheter through culprit lesion Heavily calcified vessels Previous Percutaneous coronary intervention / Coronary artery bypass grafting Anorexia nervosa Bulimia Pregnancy Lactation Athletes , high intensity sports , body building Any recent hospitalisation in past 3 months The patient has not routinely participated in caloric restriction (deliberate limitation of caloric intake of 12 hours at a time) for at least a year, and does not deliberately skip meals as a routine dietary practice. Treatment with immunosuppressive medications, or solid organ transplantation within 1 year. Diabetes or use of insulin Migraine Epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in participant plague volume Change from baseline in participant culprit lesion and in stent restenosis Change from baseline in participant plague tissue component percentage change at one year : Percentage change in necrotic , fibrotic , lipid and calcific tissue volume Number of plagues regressed , progressed and new plagues Difference in cardiac events between both groups Incidence of new onset diabetesTimepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in visceral fat , lipid profile , insulin resistance , CRP , neutrophil/lymphocytr ratio to plague volume and composition Timepoint: 1 year | — |
Countries
India
Contacts
Public ContactRohit Walia
All India Institute of Medical Science , Rishikesh
Outcome results
None listed