Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Propofol with Ketamine (Ketofol): Propofol 1mg/kg+ Ketamine 1mg/kg, Propofol 1.5mg/kg+ Ketamine 0.5mg/kg Intravenous induction dose
Control Intervention1: Not applicable: Not applicable
Sponsors
Government Mohan Kumaramangalam Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: American Society of Anaesthesiologists- Physical status 1 and 2 Patients undergoing elective surgical procedure requiring Endotracheal intubation
Exclusion criteria
Exclusion criteria: History of Cardiovascular of neurological disease Pregnancy Psychiatric disorders Contraindication or allergies to propofol or ketamine Emergency surgeries
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BIS values at various intervals Time for loss of verbal contact Time for loss of eye lash reflexTimepoint: Eleven time points: Time 1, BIS at baseline; Time 2, Time at loss of verbal contact; Time 3, BIS at 5 seconds after loss of verbal contact; Time 4, Time at loss of eye lash reflex; Time 5, BIS at 5 seconds after loss of eyelash reflex; Time 6, BIS at 2 minutes after induction; Time 7, BIS before intubation; Time 8,BIS after intubation; Time 9, BIS at 5 minutes; Time 10, BIS at 10 minutes; Time 11, BIS at 20 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic Blood Pressure Diastolic Blood Pressure Mean Arterial PressureTimepoint: Baseline After Induction After Intubation 5 minutes 10 minutes 20 minutes | — |
Countries
India
Contacts
Public ContactDr G Manjeth kumar
Government Mohan Kumaramangalam Medical College and Hospital
Outcome results
None listed