Health Condition 1: C509- Malignant neoplasm of breast of unspecified site
Conditions
Interventions
Intervention1: For Oestrogen receptor positive primary breast cancer, drug Tamoxifen is given 20mg once a day in morning after food for a period of 7 days: to assess the decrease in profilerative indi
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: All adult patients with Estrogen receptor positive breast cancer, who are candidate for primary breast surgery will be included.
Exclusion criteria
Exclusion criteria: 1.Past history of thromboembolism, uterine cancer, stroke, deep vein thrombosis or pulmonary embolism 2.Previous chemotherapy or hormonal therapy for breast cancer 3.Patient on anticoagulant therapy 4.Retinal disorders 5.Active neurological or psychological disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the effect of 7 days of oral tamoxifen on Ki 67 expression in Estrogen receptor positive breast cancerTimepoint: Immediately after 7 days of tamoxifen intake, patient undergoes breast surgery and Ki67 levels are assessed in postoperative specimen | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess 1.the patients adherence to short course tamoxifen therapy 2.the change in p53 and grade of tumor with short course tamoxifen Timepoint: immediately after 7 days usage of tamoxifen | — |
Countries
India
Contacts
Public ContactDr Balamurugan s
JIPMER
Outcome results
None listed