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Comparison of two plasma derivates as pulpotomy agents in human immature molars

Comparative evaluation of Platelet Rich Plasma (PRP) and Platelet Rich Fibrin (PRF) as pulpotomy agents in young permanent molars: A Spilt Mouth Radomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/06/025938
Enrollment
50
Registered
2020-06-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Platelet Rich Plasma: One ml of peripheral venous blood will be drawn from the patientâ??s median cubital vein and transferred into a sterile evacuated 10 ml tube containing acetic acid
top-most platelet poor plasma (PPP) layer, middle buffy layer, and bottom- most red blood cell layer. Using a sterile micro pipette, the PPP and buffy layer will be collected in a 5ml sterile glass tu
platelet poor plasma at the surface, PRF clot in the middle, and red blood cells at the bottom. Sterile tweezers will be inserted into a test tube to retrieve the PRF clot. The platelet fibrin membran

Sponsors

Terna Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Large carious or mechanical exposure (more than 1 mm) of the vital coronal pulp 2. Absence of symptoms indicative of advanced pulpal inflammation such as spontaneous pain or history of nocturnal pain 3. Absence of clinical signs or symptoms suggesting a nonvital tooth such as suppurating sinus, soft tissue swelling. 4. Restorable tooth structure. 5. Bleeding should be controlled from the amputated pulp stumps within 5 minutes using sterile moist cotton pellets. 6. No evidence of external and/or internal root resorption 7. No widening of periodontal ligament (PDL) space 8. Absence of furcal or periapical radiolucency 9. Absence of canal calcification or pulp stone.

Exclusion criteria

Exclusion criteria: 1. Uncontrolled bleeding during the amputation of coronal pulp tissue 2. Children with medical conditions or any associated systemic condition

Design outcomes

Primary

MeasureTime frame
Comparison of clinical success of PRP and PRFTimepoint: 3 months

Secondary

MeasureTime frame
Comparison of clinical and radiographic success of PRP and PRFTimepoint: 6 months and 12 months

Countries

India

Contacts

Public ContactDr Devendra Patil

Terna Dental College

dev1987endra@gmail.com9930372999

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026