Opioid based Vs Opioid sparing anaesthesia in spine surgery

Comparing the recovery profiles of opioid based Vs. opioid sparing anaesthesia technique in patients undergoing 1 - 3 levels of cervical, thoracic and lumbar laminectomy with or without discectomy Ã¢â?¬â?? A double blinded Randomized controlled trial. - Nil

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/06/025924

Enrollment

200

Registered

2020-06-16

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G319- Degenerative disease of nervous system, unspecified

Interventions

Intervention1: Multimodal non-opioid drugs such as Pregabalin, Ketamine, Xylocaine(Preservative free): 1. T.Pregabalin 75mg one dose at night before surgery second dose along with premedication and th

Eligibility

Inclusion criteria

Inclusion criteria: All ASA 1 and 2, adult patients aged 18-70 years undergoing laminectomy with or without discectomy (cervical, thoracic, and lumbar)in prone position for degenerative spine disease.

Exclusion criteria

Exclusion criteria: Hypersensitivity to Pregabalin Psychiatric Illness ASA 3, 4 patients Allergy to local anaesthetic agents Morbid obesity BMI > 35 Obstructive Sleep Apnoea Serum Creatinine > 1.4 mg% Previous surgical procedure at the same level Surgeries where intraoperative neuromonitoring is needed

Design outcomes

Primary

Measure	Time frame
The quality of recovery using QoR-15 scoreTimepoint: at 24 hour after surgery	—

Secondary

Measure	Time frame
1 1.Time taken to drink,eat, ambulate 2. NRS score at 2,6,8,12,18,24 hours after surgery. 3.Opioid induced side effects 4.Time taken for receiving the first dose of rescue analgesia 5 post operative haemodynamicsTimepoint: During the first 24 hours	—

Countries

India

Contacts

Public ContactShefali William

CHRISTIAN MEDICAL COLLEGE , VELLORE

ramamani@cmcvellore.ac.in9443753184

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026