Can Volumetric modulated arc radiotherapy spare the thyroid gland in the treatment of head and neck cancers

Pilot study to evaluate the feasibility of thyroid sparing Volumetric Modulated Arc Radiotherapy in the management of locally advanced head and neck cancers.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/06/025863

Enrollment

Registered

2020-06-15

Start date

Unknown

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C01- Malignant neoplasm of base of tongue Health Condition 2: C13- Malignant neoplasm of hypopharynx Health Condition 3: C10- Malignant neoplasm of oropharynx Health Condition 4: C02- Malignant neoplasm of other and unspecified parts of tongue Health Condition 5: C321- Malignant neoplasm of supraglottis

Interventions

Intervention1: Radical RT (66-70 Gy) using SIB-VMAT thyroid sparing technique: A dose volume constraint will be given to the thyroid gland where volume of thyroid gland receiving 50 Gy will be less th

Eligibility

Inclusion criteria

Inclusion criteria: 1 Squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx and hypopharynx 2 Locally advanced disease (Stage III , IV) 3 Histological proof of malignancy 4 Patients treated with radical intent

Exclusion criteria

Exclusion criteria: 1. Patients with Nasopharyngeal malignancies 2. Patients who have thyroid dysfunction or are known to have thyroid dysfunction during baseline investigations 3. Prior radiotherapy, chemotherapy or head and neck surgery 4.Thyroid malignancies or tumours involving the thyroid gland

Design outcomes

Primary

Measure	Time frame
1. To study the feasibility of achieving the dose volume constraints to the thyroid gland using Volumetric modulated arc radiotherapy (VMAT) technique. 2. To evaluate the Dose volume histogram(DVH) coverage of Clinical target volume(CTV) and Planning target volume (PTV) nodal volumes with and without thyroid sparing radiotherapy techniques.Timepoint: Study duration is for 2 years with a sample size of 20 patients	—

Measure

Time frame

1. To study the feasibility of achieving the dose volume constraints to the thyroid gland using Volumetric modulated arc radiotherapy (VMAT) technique. 2. To evaluate the Dose volume histogram(DVH) coverage of Clinical target volume(CTV) and Planning target volume (PTV) nodal volumes with and without thyroid sparing radiotherapy techniques.Timepoint: Study duration is for 2 years with a sample size of 20 patients

—

Secondary

Measure	Time frame
1. To evaluate the thyroid profile at the end of radiotherapy , 6 months and 12 months for the two study arms. 2. To evaluate the progression free survival at last follow up in both the study arms.Timepoint: Last follow up of 1 yr after treatment completion in both arms	—

Countries

India

Contacts

Public ContactDr Amit Bahl

Post graduate institute of medical education and research

dramitbahl@yahoo.com6283774431

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026