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Conception with oral contraceptive pills plus letrozole vs letrozole alone among infertile couples

Randomised controlled trial to study the difference in follicular growth in infertile patients receiving a prior cycle of oral contraceptive pills followed by Letrozole vs Letrozole alone

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/06/025842
Enrollment
162
Registered
2020-06-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Letrozole with oral contraceptive pills vs only letrozole for 1 cycle: Letrozole with oral contraceptive pills vs only letrozole for 1 cycle Control Intervention1: NA: NA

Sponsors

INHS Asvini
Lead Sponsor
Dr Ashalass
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: a. Primary infertility under WHO 2 criteria of anovulation(normogonadotrophic normogonadism) b. Secondary infertility under WHO 2 criteria of anovulation(normogonadotrophic normogonadism) c. Polycystic ovary syndrome

Exclusion criteria

Exclusion criteria: a. Male factor infertility b. Genital Kochs c. Pelvic inflammatory disease d. Endometriosis e. Anatomical abnormality f. Previous IVF pregnancy g. Previous IUI pregnancy h. Previous ovulation induction I. Previous abdominal/ pelvic surgery

Design outcomes

Primary

MeasureTime frame
Ovulation, assessed by a. Follicular monitoring by transvaginal sonography on day 6 of missed period b. LH surge by using urinary LH kitsTimepoint: TVS on day 6 of missed period—

Secondary

MeasureTime frame
Pregnancy a. UPT positive test results b. Appearance of gestational sac on TVS on day 10th of missed periodTimepoint: Day 10 and 5th week of missed period—

Countries

India

Contacts

Public ContactDr PR LELE

INHS Asvini

prasadlele@hotmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026