Health Condition 1: C61- Malignant neoplasm of prostate
Conditions
Interventions
None listed
Sponsors
Department of Atomic Energy
Eligibility
Inclusion criteria
Inclusion criteria: •Willing to give informed consent •Age group: 40 years and older • For PCa tissues: 1. Suspicious palpatory prostate findings on DRE (Digital RectalExamination) or TRUS (Trans Rectal Ultra Sonography) 2.Raised PSA levels 4-10 ng/mL and above and undergoing Core NeedleBiopsy (CNB) 3.To choose locally advanced and metastatic prostate cancer patients withpossible dense involvement of cores[Late stage] 4.To consider four additional cores of prostate tissue to be collected from Transrectal Ultrasound guided multiple core needle biopsy that would be a part of evaluation for suspected metastatic prostate cancer patients For BPH tissues:Patients undergoing (trans Urethral Resectioning of Prostate)TURPsurgery for BPH For normal prostate (cadaver tissue)Normal/benign prostatic tissue will be obtained from cadavers from KEM following signed consent from relatives The tissue/sections will be analysedhistologically for presence of BPH or cancerous phenotype
Exclusion criteria
Exclusion criteria: Group I: •Those who have been diagnosed and treated outside TMH and undergoing repeat biopsy Group II: • BPH patients with elevated PSA levels ( >10 ng/mL) showing positivecancerous foci on prospective histopathological examination group III: If any tissue obtained histologically shows a BPH or cancerous phenotype then such tissues will be not be considered in the study group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study will help elucidate for the first time whether estrogen receptors are localized to the cell surface of normal, BPH and cancerous prostate cells. It will also establish whether there is a difference in the expression of these csERs in patients with BPH and PCa. The study will also help elucidate the events triggered by the activation of these cell ERs.Timepoint: Two years | — |
Secondary
| Measure | Time frame |
|---|---|
| NATimepoint: NA | — |
Countries
India
Contacts
Public ContactDr Ganesh K Bakshi
Tata Memorial Hospital
Outcome results
None listed