Health Condition 1: F329- Major depressive disorder, singleepisode, unspecified
Conditions
Interventions
Intervention1: Escitalopram: Single arm.
Patient will be prescribed escitalopram 10 mg per day which will be given by oral route. However, if patient could not tolerate the starting dose, then it will
Sponsors
Government Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1)Diagnosis of Major depressive disorder according to DSM-5 2)Hamilton depression Rating Scale score more than 7 3)Treatment naive patients or Recurrent depressive disorder patients who are off medications for at least last two weeks and current HAM-D score is more than 7
Exclusion criteria
Exclusion criteria: 1)Patient having acute infections and chronic diseases(e.g. cancer, HIV, diabetes, cardiovascular disease or stroke,etc.),which has any association or impact on telomerase activity. 2)Substance Dependence(excluding nicotine and caffeine) in past six months. 3)Pregnant or breast feeding females 4)Actively suicidal patients 5)Major depressive disorder with psychotic features according to DSM-5 6)Patients having hypersensitivity to Escitalopram in the past or any history of adverse reaction with drug in the past
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)To assess and compare activity of telomerase enzyme between patients of depression and healthy controls. 2)To study the association of telomerase enzyme activity with severity of depression and treatment response. Timepoint: Baseline,2nd week,4th week,6th week,8th week | — |
Secondary
| Measure | Time frame |
|---|---|
| To see the response on HAM-DTimepoint: Baseline,2nd week,4th week,6th week,8th week | — |
Countries
India
Contacts
Public ContactDr Ajeet Sidana
Government Medical College and Hospital Sector 32 Chandigarh
Outcome results
None listed