Health Condition 1: G409- Epilepsy, unspecified
Conditions
Interventions
Control Intervention1: Nil: Nil
Sponsors
Bharati Medical foundation
Eligibility
Inclusion criteria
Inclusion criteria: Cases: Patients attending pediatric and adult epilepsy clinic, who are on different anti-epileptic drugs will be screened for past history of drug related rash or new onset rash and a detailed questionnaire will be filled; regarding age of diagnosis, duration of AED, which AED etc. Patients with epilepsy who are on treatment with AED and who have a newly diagnosed or past history of drug induced cutaneous eruptions (rash) on treatment with AED(not deemed to be due to any other cause); and due to which that particular drug was withdrawn. Controls: Patients will be taken from the same clinic, those who are on anti-epileptic drug/s for at least 3 months,but never had any cutaneous reactions.
Exclusion criteria
Exclusion criteria: (i). All patients who have any pre-existing chronic skin disorders like psoriasis, eczema (ii). Patients with known chronic systemic diseases known to be associated with rash (like pemphigus, SLE, vasculitis, etc.) (iii). Patients who are immunocompromised (like primary immunodeficiency disorders, HIV/AIDS) or on drugs which cause immunosuppression (like steroids) (iv). Patients with rash due to accompanying acute conditions like measles, dengue etc. (v). Patients in whom multiple drug additions have been done in last 3 months, due to which it is difficult to ascertain the drug responsible for cutaneous reaction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Prevalence ratio of prevalence of HLA B 15:02 carrier status in those with rash versus those without rashTimepoint: 9 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Prevalence ratio of patients with positive HLA B 15:02 carrier status in those on aromatic AED with rash on other AED. 2. Prevalence ratio of prevalence of HLA A 31:01 carrier status in those with rash versus those without rash Timepoint: 9 months | — |
Countries
India
Contacts
Public ContactDr Kavita Srivastava
Bharati Vidyapeeth Deemed to be University Medical College, Pune
Outcome results
None listed