Changes in pulse rate and blood pressure during anaesthesia with two types of drugs

Efficacy of dexmedetomidine versus esmolol in Attenuating haemodynamic response to laryngoscopy and endotracheal intubationin

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/06/025700

Enrollment

Registered

2020-06-08

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N202- Calculus of kidney with calculus of ureter

Interventions

Intervention1: Esmolol: Esmolol 0.5mg/kg will be given over 10 min as an intravenous infusion before induction of general anesthesia Control Intervention1: Dexmedetomidine: Dexmedetomidine 0.5mcg/kg w

Eligibility

Inclusion criteria

Inclusion criteria: 1)American Society of Anaesthesiologists grade 1 and 2 underoing elective surgery 2) age group 20 to 80 years

Exclusion criteria

Exclusion criteria: 1.Thyrotoxicosis 2.Pheochromocytoma 3.Patient With difficult airway 4.Patient on beta blockers or alpha blockers 5.Allergy to either of the study drugs

Design outcomes

Primary

Measure	Time frame
To compare the effect of dexmedetomidine and esmolol on the change in heart rate from baseline to 1 minute after laryngoscopy and intubation.Timepoint: 1 minute after laryngoscopy and intubation.	—

Secondary

Measure	Time frame
Change in systolic BP, diastolic BP and MAP from base line to predinduction, just before intubation and to 1 minute, 4 minute, 7 minute and 10 minute after laryngoscopy and intubation.Timepoint: 1 minute, 4 minute, 7 minute and 10 minute after laryngoscopy and intubation.	—

Countries

India

Contacts

Public ContactDr Roniya Ann Roy

Amrita Institute of Medical Sciences

rajgokulam70@gmail.com9847162134

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026