Health Condition 1: E282- Polycystic ovarian syndrome
Conditions
Interventions
Intervention1: Combination of Letrozole and Clomiphene Citrate Versus Letrozole alone for ovulation induction in women with polycystic ovary syndrome-a Randomized Controlled Trial: Letrozole 2.5 mg +
Sponsors
Dr Anupama Bahadur
Eligibility
Inclusion criteria
Inclusion criteria: 1-Women 20â??35 years of age with PCOS(according to Rotterdam criteria). 2-Primary / Secondary Infertile women with PCOS 3-BMI 4-Willing to participate in study and follow up
Exclusion criteria
Exclusion criteria: 1-Pregnancy 2-Patient already on other drugs for treatment of PCOS like OCPs 3-Other known cause of infertility (Endometriosis, Unexplained Infertility, Moderate to severe male factor infertility) 4-Deranged kidney or liver function tests 5-Uncontrolled Thyroid disorders 6-Untreated hyperprolactinemia 7-Women with any other endocrinological disorders 8-Medical conditions not well controlled or not recommended during pregnancy (i.e., uncontrolled type 1 or 2 diabetes mellitus, hypertension, hypothyroidism) 9-Allergy or contraindications to letrozole or CC 10-Clinical suspicion of other etiologies that mimic PCOS warranting additional evaluation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total number of women attaining clinical pregnancy in either group (confirmed by USG)Timepoint: 18 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ovulation rate 2. Number of OHSS(Ovarian Hyper-Stimulation Syndrome) cases 3. Number of abortions 4. Numberof ectopic or multiple pregnancies Timepoint: 18 months | — |
Countries
India
Contacts
Public ContactDr Anupama Bahadur
All India Institute Of Medical Sciences, Rishikesh
Outcome results
None listed