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Understanding the relationship of host gut microbiota and immune response to patients outcome in Melioidosis

Understanding the relationship of host gut microbiota and host immune response to patients outcome in Melioidosis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/06/025663
Enrollment
120
Registered
2020-06-05
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A488- Other specified bacterial diseases

Interventions

None listed

Sponsors

Indian Council of Medical Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All melioidosis cases with or without comorbidities (diabetes, alcoholism, renal disease etc.). Individuals having no signs and symptoms of fever, pneumonia, abscess, lymphadenitis and no past history of hospitalization for last 3 months.

Exclusion criteria

Exclusion criteria: Pregnant women. Individuals with disease like arthritis, malignancy and on immunosuppressive therapy. The patients with above mentioned chronic diseases might have a negative impact that giving to a false positive result in seroprevalence study.

Design outcomes

Primary

MeasureTime frame
This study will provide information about the difference in the gut microbiota among localized versus disseminated infection.The changes in abundance of gut microbiota between melioidosis cases and seropositive individual. The influence of long-term antibiotic treatment on the abundance of gut microbiots in patients.Timepoint: 2020-2023. Gut microbiota analysis with Journal publication-2020-2021.

Secondary

MeasureTime frame
The differences in cytokine expression of disseminated versus localized melioidosis with prognosis and outcome of patients having comorbiditiesTimepoint: Cytokine analysis with journal publications - 2021-2023.

Countries

India

Contacts

Public ContactSoumi Chowdhury

Kasturba Medical College

soumi.sia1995@gmail.com9475138726

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026