To compare platelet inhibition with crushed versus whole tablet administration of clopidogrel and ticagrelor in patients with acute coronary syndrome undergoing percutaneous intervention procedure.

Comparing platelet inhibition with crushed versus integral pill administration of clopidogrel and ticagrelor in patients with acute coronary syndrome undergoing percutaneous intervention

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/06/025647

Enrollment

144

Registered

2020-06-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I22- Subsequent ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Interventions

Intervention1: Clopidogrel 600 mg, loading dose only, crushed formulation per oral adminstration.: Antiplatelet loading dose is crushed and adminstered mixed with 25-50 ml of water. Intervention2: Tic

Eligibility

Inclusion criteria

Inclusion criteria: Patients presenting within 12 hours from the onset of symptoms with ACS as per ACC/AHA criteria and undergoing PCI. Patients giving informed consent obtained in writing.

Exclusion criteria

Exclusion criteria: Age 75 years. Inability to give informed consent. Active bleeding; bleeding diathesis; coagulopathy History of GI, I.C, genitourinary or other site abnormal bleeding Suspected aortic dissection Known relevant hematological deviations: Hb Known severe liver disease, severe renal failure Pregnancy/breastfeeding. Allergy / Hypersensitivity.

Design outcomes

Primary

Measure	Time frame
Residual Platelet Reactivity by Platelet Reactivity Units (PRU) in the 4 groupsTimepoint: Time Frame: 1 hour after loading dose	—

Secondary

Measure	Time frame
Bleeding EventsTimepoint: Time Frame: 48 hours;High Residual Platelet Reactivity/antiplatelet resistanceTimepoint: Time Frame: 1 hour;Patient comfort during administration of loading dose by Visual Analogue Scale (VAS) â?? scored from 0-10Timepoint: after loading dose	—

Countries

India

Contacts

Public ContactPerla Harsha Teja

Christian Medical College Vellore

harsha.tej@gmail.com9894659530

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 11, 2026