Health Condition 1: G473- Sleep apnea
Conditions
Interventions
Intervention1: Mandibular advancement device: Patients with obstructive sleep apnoea will be given intervention with treatment by mandibular advancement device and observed.
Control Intervention1: NIL
Sponsors
Office of the Research Cell
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subjects in the age group of 25-65 years. 2. Ability to understand the procedure and provide informed consent before being included in the study. 3. Patients with mild to moderate Obstructive Sleep Apnoea. 4. Patients with no previous OSA treatment history. 5. >8 stable natural teeth per jaw with no periodontal condition like periodontitis etc.
Exclusion criteria
Exclusion criteria: 1. Current smoking habit with moderate to heavy smoking (more than 10 cigarettes per day). 2. History of infectious diseases, rheumatic diseases, immunological diseases, tumours, peripheral vascular diseases, coagulation disorders, severe psychogenic disorders, or acute or chronic kidney failure. 3. History of injury or surgery in past three months. 4. Administration of drugs (anti-inflammatory, TNF- α blockers), hormones, immune suppressors, cytotoxins, free radical scavengers. 5. OSA patients already receiving/received treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum TNF-alpha levelsTimepoint: Baseline 3 months 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Epworth sleepiness scale Berlin questionnaire Stop-Bang questionnaireTimepoint: baseline 3 months 6 months | — |
Countries
India
Contacts
Public ContactNeeti Solanki
King Georges Medical University
Outcome results
None listed