Health Condition 1: E101- Type 1 diabetes mellitus with ketoacidosis
Conditions
Interventions
Intervention1: Low dose insulin 0.05U/kg/hr: 1.Capillary or venous blood glucose will be checked every hour or more frequently depending on clinical need. (On call Plus glucometer, ACON laboratories.
Sponsors
Institute of Child Health and Hospital for Children
Eligibility
Inclusion criteria
Inclusion criteria: All children between 1 month to 12 years diagnosed as DKA - defined as blood glucose more than 200mg/dl with acidosis pH less than 7.3 or bicarbonate less than 15mEq/l and ketonuria(urine dipstick result more than or equal to 2+/ketonemia >3mmol/L)
Exclusion criteria
Exclusion criteria: All children diagnosed as DKA and started on insulin in other hospital
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To measure the rate of decrease in blood glucose until the level reaches 200mg/dl or less 2) to assess the time taken for resolution of acidosis- normalisation of anion gapTimepoint: 1.enrollment will be done within one hour of admission 2.intervention will start at the time of enrollment 3. As per ISPAD guidelines, patient will be assessed every hour for measuring the rate of decrease of blood glucose and every 4 hours for resolution of acidosis | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the incidences of complications like hypokalemia, hypoglycaemia and cerebral edemaTimepoint: 1.enrollment will be done within one hour of admission 2.intervention will start at the time of enrollment 3.As per ISPAD guidelines, patient will be assessed every hour for hypoglycemia and for cerebral edema 4. patient will be assessed every fourth hour for hypokalemia | — |
Countries
India
Contacts
Public ContactProf Dr V Poovazhagi
Institute of child health and hospital for children, Madras Medical College
Outcome results
None listed