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Bolus dosages of Norepinephrine,phenylephrine and ephedrine for spinal induced Hypotension in parturients undergoing elective caesarean section.

A STUDY OF BOLUS DOSAGES OF NOREPINEPHRINE, PHENYLEPHRINE AND EPHEDRINE FOR TREATMENT OF SPINAL INDUCED HYPOTENSION IN PARTURIENTS DURING CAESAREAN DELIVERY - A THREE ARM DOUBLE BLINDED RANDOMIZED CONTROL STUDY.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/06/025626
Enrollment
135
Registered
2020-06-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O30-O48- Maternal care related to the fetus and amniotic cavity and possible delivery problems

Interventions

Intervention1: NOREPINEPHRINE VS PHENYLEPHRINE VS EPHEDRINE: EFFICACY AND POTENCY OF THE DRUGS(NOREPINEPHRINE 6mcg vs PHENYLEPHRINE 100mcg vs EPHEDRINE 6mg) ON SPINAL INDUCED HYPOTENSION IN PARTURIENT

Sponsors

S NIJALINGAPPA MEDICAL COLLEGE AND HSK HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age between 18 to 35 years. 2.Body mass index 3.Singleton pregnancies at term scheduled for elective cesarean section under spinal anesthesia

Exclusion criteria

Exclusion criteria: 1.ASA status III and IV. 2.Emergency caesarean section. 3.Active labour. 4.High risk pregnancies ( Intrauterine growth retardation, preeclampsia) 5.Maternal cardiovascular and pulmonary diseases. 6.Foetal abnormalities 7.History of diabetes excluding Gestational diabetes 8.Patients on MAO inhibitors and TCA. 9.Patients allergic to any of the medications used in study. 10.If block(anesthesia) level achieved higher than T4. 11.Height less than 140cm or more than 180cm

Design outcomes

Primary

MeasureTime frame
To compare the efficacy(potency) and safety of bolus dosages of Norepinephrine, Phenylephrine, Ephedrine in elective parturient women to treat hypotension during caesarean delivery under spinal anaesthesia. Timepoint: Number of blous dosages of drug needed to treat maternal hypotension,number of episodes of maternal hypotension occurred before delivery of baby and fetal outcomes immediately after birth (to prove most potent and effective drug to treat maternal hypotension intra operatively 1st 12 minutes following performing spinal anaesthesia)—

Secondary

MeasureTime frame
1.Assessing number of episodes of bradycardia (HR less than60 bpm), tachycardia (HR less than 120 bpm) hypertension(SBP greater than20% of baseline) and number of hypotension episodes occurred. 2.Assessing number of vasopressor boluses required to treat post spinal hypotension 3. Assessing maternal side effects like nausea, vomiting, dizziness and shivering. 4.Assessing neonatal outcome, including Apgar scores at one minute and five minutes, umbilical artery blood gas analysis and pH. Timepoint: 2 hours—

Countries

India

Contacts

Public ContactDr Prasanth Kumar Reddy C

S N MEDICAL COLLEGE AND HSK HOSPITAL.

anilganesh22@gmail.com9739677990

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026