None listed
Conditions
Interventions
Intervention1: validation and use of leishmanin skin test for detection of Leishmania exposure and immunity: Treated and cured VL cases and an equal number of controls will be injected (50 μg/100μl)
Sponsors
Dr Pradeep Das
Prof R Satoskar
Eligibility
Inclusion criteria
Inclusion criteria: Validation of LST for determining Leishmania exposure in an immune population: 100 treated-cured VL (with miltefosine or AmBisome) and 100 controls (from a non-endemic area with no VL). Identification of asymptomatic infections: 250 members from neighbors of PKDL cases and 250 members from non-endemic area. Age group: 15-65 years and either sex. Subjects willing to give written informed consent.
Exclusion criteria
Exclusion criteria: Co-infection with HIV or Tuberculosis Pregnant and lactating women. Anti cancer and immune suppressive drugs. Subjects not willing to give written informed consent. Subjects who are hepatitis B & C positive. Age group: 65 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This project seeks to reintroduce the LST as a tool for detection of Leishmania infection, surveillance, epidemiological studies, and future vaccine trials. With over 350 million people worldwide at risk of developing leishmaniasis, the development of a new prophylactic vaccine will have a major and far-reaching positive impact on global health.Timepoint: Two Years | — |
Secondary
| Measure | Time frame |
|---|---|
| The outcome of this project can lead to development of a vaccine for VL and thus can lead to elimination of VL from India.Timepoint: Ten Years. | — |
Countries
India
Contacts
Public ContactDr Pradeep Das
ICMR Rajendra Memorial Research Institute of Medical Sciences
Outcome results
None listed