Effect of enzyme based toothpaste on oral health

Effect of enzyme based dentifrice on plaque and gingivitis among patients undergoing orthodontic treatment â?? randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/06/025571

Enrollment

120

Registered

2020-06-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K051- Chronic gingivitis

Interventions

Intervention1: enzyme based toothpaste: Lactoperoxidase based toothpaste Patient has to brush teeth twice daily for 4 weeks with this toothpaste. Control Intervention1: Control: Colgate total tooth pa

Eligibility

Inclusion criteria

Inclusion criteria: Participants undergoing orthodontic treatment with plaque and gingivitis of more than score 2. Participants who are willing to participate. Participants who can comprehend in English.

Exclusion criteria

Exclusion criteria: Participants with a history of use of antibiotics or anti-inflammatory drugs in the last one week, allergy to any ingredients of the dentifrice or rampant caries. Participants with more than 30% of the teeth missing or crowns or large restorations or calculus.

Design outcomes

Primary

Measure	Time frame
Gingivitis reduction Plaque ReductionTimepoint: Day 0 and day 28	—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactKalyana Chakravarthy Pentapati

Manipal College of Dental Sciences

drkalyan81@gmail.com09916036303

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026