Health Condition 1: E282- Polycystic ovarian syndrome
Conditions
Interventions
Intervention1: letrozole and clomiphene citrate: Intervention group will receive tablet letrozole 2.5mg and clomiphene citrate 50 mg daily orally for five days from day two of the menstrual cycle. If
Sponsors
All India Institute of Medical Sciences BHUBANESWAR INTRAMURAL GRANT
Eligibility
Inclusion criteria
Inclusion criteria: Women from age of 18-40 years diagnosed with subfertility with PCOS and no other detectable cause of infertility. Proven patency of at least one fallopian tube. Sperm count of 15 million/ml and more than 40% motility will be included.
Exclusion criteria
Exclusion criteria: Women having other cause of subfertility. Recent use of hormonal contraception. Hyperprolactinemia, untreated thyroid disease, uncontrolled diabetes. Drug allergy or contraindication to letrozole or clomiphene citrate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Conception: a positive serum or urinary test of hCGTimepoint: 1-3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Number and size of developing follicle on day 12-14, endometrial thickness on day 12-14, clinical pregnancy: an intrauterine gestational sac, complication related to study medicationTimepoint: 1-3 months | — |
Countries
India
Contacts
Public ContactPruthwiraj Sethi
All India Institute of Medical Sciences, Bhubaneswar
Outcome results
None listed